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INGREDIENT OF THE WEEK: AGMATINE SULFATE

JUNE 29, 2016

    Agmatine Sulfate is a biogenic amine that is derived from the amino acid L-Arginine. This occurs due to a process called decarboxylation, which is the removal of a carboxylic acid group from the amino acid. In result, Agmatine Sulfate appears to be stored with the neurons of the brain and is released as these neurons become activated. Agmatine has several mechanisms. It can inhibit N-methyl-D-aspartate (NMDA) and nicotinic acetylcholine receptors, as well as activate imidazoline receptors. Agmatine can also inhibit nitric oxide synthase enzymes, which allows it to regulate elevated levels of nitric oxide and can inhibit calcium channels and certain serotonin receptors as well. Agmatine is considered to be a neurotransmitter and neuromodulator. The primary method of action for Agmatine Sulfate is by crossing the blood-brain barrier, entering into the central nervous system, and then binding to NMDA Glutamate receptors. It has potential use in the treatment of neuropathic pain and drug addiction. It also protects the brain from toxins and strokes. Though supplementing Agmatine by itself can increase the perception of pain, it works synergistically with painkillers like morphine and fentanyl. Agmatine synergy with opioids allows it to reduce pain killer tolerance, the possibility of addiction, and pain itself. The supplement also appears to help regulate the levels of Nitric Oxide. Agmatine Sulfate also has some analgesic activities, releasing a number of opioid and endorphin chemicals, seeming to have some sort of synergistic effect on many of these chemicals. The supplement supports a healthy mood, has anti-anxiety properties, and may also stack very well with other Nootropic supplements. Agmatine Sulfate also acts as an antioxidant. Part of this benefit is due to the fact that it helps to limit the activity of Glutamate and thus, over excitation of the brain. Many people will take Agmantine Sulfate to prevent excitotoxicity which can occur when using too much Sunifiram, Unifiram, Modafinil or other similar nootropic supplements. Removal of free radicals, toxins, and other poisons can help to keep not only the brain but the entire body in a better state of health.

There are also a number of athletic effects. This includes enhancing and improving insulin response of the body. This has long been thought to be one of the biggest keys to building a leaner, harder, and more muscular body. The supplement is additionally thought to stimulate the production and increase of GH and LH hormones which can also have positive effects upon overall body composition. Due to the regulation of Nitric Oxide levels in the body, Agmatine Sulfate may also lead to better muscle “pumps” in weight training athletes. The idea of being able to protect the brain, relieve pain, and help increase insulin production and response from a single supplement does sound extraordinary. Agmatine Sulfate is one of the best “well-rounded” nutrients and has many advantages for anyone looking for that extra edge.